Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer

L Colucci-D'Amato, L Speranza, F Volpicelli - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity

P Kowiański, G Lietzau, E Czuba, M Waśkow… - Cellular and molecular …, 2018 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …

Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

M Notaras, M van den Buuse - Molecular psychiatry, 2020 - nature.com
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …

Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants

RS Duman, S Deyama… - European Journal of …, 2021 - Wiley Online Library
The pathophysiology and treatment of depression have been the focus of intense research
and while there is much that remains unknown, modern neurobiological approaches are …

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

R Ward, W Li, Y Abdul, LD Jackson, G Dong… - Pharmacological …, 2019 - Elsevier
Diabetes increases the risk and worsens the progression of cognitive impairment via the
greater occurrence of small vessel disease and stroke. Yet, the underlying mechanisms are …

Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways

T Jin, Y Zhang, BOA Botchway, J Zhang, R Fan… - Food and Chemical …, 2022 - Elsevier
Parkinson's disease is a common progressive neurodegenerative disease, and presently
has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in …

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

A Wu, J Zhang - Journal of Neuroinflammation, 2023 - Springer
As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

The role of altered BDNF/TrkB signaling in amyotrophic lateral sclerosis

J Pradhan, PG Noakes, MC Bellingham - Frontiers in cellular …, 2019 - frontiersin.org
Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions,
via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition …

Brain-derived neurotrophic factor (BDNF): novel insights into regulation and genetic variation

M Notaras, M van den Buuse - The Neuroscientist, 2019 - journals.sagepub.com
Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that
now spans 35 years of research. While all neurotrophins share considerable overlap in …

Mechanisms controlling the expression and secretion of BDNF

JC Arévalo, R Deogracias - Biomolecules, 2023 - mdpi.com
Brain-derived nerve factor (BDNF), through TrkB receptor activation, is an important
modulator for many different physiological and pathological functions in the nervous system …