Protein hydroxylation by hypoxia-inducible factor (HIF) hydroxylases: unique or ubiquitous?

MJ Strowitzki, EP Cummins, CT Taylor - Cells, 2019 - mdpi.com
All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to
adapt to hypoxia, the condition that arises when O2 demand exceeds supply. This is …

Chemical glycoproteomics

KK Palaniappan, CR Bertozzi - Chemical reviews, 2016 - ACS Publications
Chemical tools have accelerated progress in glycoscience, reducing experimental barriers
to studying protein glycosylation, the most widespread and complex form of posttranslational …

Current trends in the analysis of post-translational modifications

D Virág, B Dalmadi-Kiss, K Vékey, L Drahos… - Chromatographia, 2020 - Springer
Post-translational modifications controlling a large number of biological functions are key
aspects of protein diversity. They have an important role controlling cellular processes and …

Posttranslational modifications and the immunogenicity of biotherapeutics

R Jefferis - Journal of immunology research, 2016 - Wiley Online Library
Whilst the amino acid sequence of a protein is determined by its gene sequence, the final
structure and function are determined by posttranslational modifications (PTMs), including …

Western blotting: a powerful staple in scientific and biomedical research

H Begum, P Murugesan, AD Tangutur - Biotechniques, 2022 - Taylor & Francis
Western blotting (WB), also known as immunoblotting, is a well-known molecular biology
method that biologists often use to investigate many features of the protein, ranging from …

Applications of infrared multiple photon dissociation (IRMPD) to the detection of posttranslational modifications

P Maitre, D Scuderi, D Corinti, B Chiavarino… - Chemical …, 2019 - ACS Publications
Infrared multiple photon dissociation (IRMPD) spectroscopy allows for the derivation of the
vibrational fingerprint of molecular ions under tandem mass spectrometry (MS/MS) …

Protein S-nitrosylation: specificity and identification strategies in plants

O Lamotte, JB Bertoldo, A Besson-Bard… - Frontiers in …, 2015 - frontiersin.org
The role of nitric oxide (NO) as a major regulator of plant physiological functions has
become increasingly evident. To further improve our understanding of its role, within the last …

The role of mass spectrometry in the characterization of biologic protein products

D Rathore, A Faustino, J Schiel, E Pang… - Expert review of …, 2018 - Taylor & Francis
Introduction: Mass spectrometry (MS) is widely used in the characterization of biomolecules
including peptide and protein therapeutics. These biotechnology products have seen rapid …

Mass spectrometry as a crucial analytical basis for omics sciences

VG Zaikin, RS Borisov - Journal of Analytical Chemistry, 2021 - Springer
This review is devoted to the consideration of mass spectrometric platforms as applied to
omics sciences. The most significant attention is paid to omics related to life sciences …

Genome annotation of a model diatom Phaeodactylum tricornutum using an integrated proteogenomic pipeline

M Yang, X Lin, X Liu, J Zhang, F Ge - Molecular plant, 2018 - cell.com
Diatoms comprise a diverse and ecologically important group of eukaryotic phytoplankton
that significantly contributes to marine primary production and global carbon cycling …