Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Mutations in the glucocerebrosidase gene (GBA), which cause Gaucher disease, are also
potent risk factors for Parkinson's disease. We examined whether a genetic burden of …

Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Clinical–pathological studies remain the gold‐standard for the diagnosis of Parkinson's
disease (PD). However, mounting data from genetic PD autopsies challenge the diagnosis …

Lysosomes, single-membrane organelles defined by a uniquely strong acidic lumenal pH
and high content of acid hydrolases, are the shared degradative compartments of the …

The cause of Parkinson's disease (PD) remains unknown in most patients. Since 1997, with
the first genetic mutation known to cause PD described in SNCA gene, many other genes …

The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative
disorders that affect children and adults and are grouped together by similar clinical features …

Lysosomal function has a central role in maintaining neuronal homeostasis, and,
accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to …

Less than a quarter century after the discovery of SNCA as the first attributable gene in
Parkinson's disease (PD), our knowledge of the genetic architecture underlying this disease …