Radiation enteritis remains a major challenge for radiotherapy against abdominal and pelvic
malignancies. Nevertheless, there is no approved effective therapy to alleviate irradiation …

The immunobiology of FXR has attracted significant attention in immune regulation and
innate immunity. We have studied the mechanism of action of FXR activation on two models …

B1 B cells secrete most of the circulating natural antibodies and are considered key effector
cells of the innate immune response. However, B1 cell-associated antibodies often cross …

Background Complex interactions between the environment and the mucosal immune
system underlie inflammatory bowel disease (IBD). The involved cytokine signalling …

Major histocompatibility complex class one (MHC-I) antigen-presenting molecules
participate in central nervous system (CNS) synaptic plasticity, as does the paired …

Neural stem cells play pivotal roles during prenatal development and throughout life. Here,
we report that Paired immunoglobulin-like receptor B (PirB) functions as a suppressor during …

Abstract Background Deer mice (Peromyscus maniculatus) are the principal reservoir hosts
of Sin Nombre virus (SNV), the cause of the great majority of hantavirus cardiopulmonary …

Background & Aims CD4+ T cells are regulated by activating and inhibitory cues, and
dysregulation of these proper regulatory inputs predisposes these cells to aberrant …

Abstract IL-9–secreting Th9 cells have been considered to play a pivotal role in the
pathogenesis of atopic diseases. To what extent IL-9–producing cells are induced or …

Rationale: The inflammatory bowel diseases (IBD), Crohn's Disease (CD) and Ulcerative
Colitis (UC) are chronic relapsing gastrointestinal (GI) inflammatory diseases that are driven …