Post-translational modifications of transporters
Drug transporter proteins are critical to the distribution of a wide range of endogenous
compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and …
compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and …
Advances in deubiquitinating enzyme inhibition and applications in cancer therapeutics
Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …
[HTML][HTML] Axonal endoplasmic reticulum Ca2+ content controls release probability in CNS nerve terminals
Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER
dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is …
dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is …
Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them
Z Xu, N Zhang, L Shi - American Journal of Cancer Research, 2024 - pmc.ncbi.nlm.nih.gov
Deubiquitinating enzymes (DUBs) are a large group of proteases that reverse ubiquitination
process and maintain protein homeostasis. The DUBs have been classified into seven …
process and maintain protein homeostasis. The DUBs have been classified into seven …
Na+/K+-ATPase is a new interacting partner for the neuronal glycine transporter GlyT2 that downregulates its expression in vitro and in vivo
J de Juan-Sanz, E Núñez… - Journal of …, 2013 - Soc Neuroscience
The neuronal glycine transporter GlyT2 plays a fundamental role in the glycinergic
neurotransmission by recycling the neurotransmitter to the presynaptic terminal. GlyT2 is the …
neurotransmission by recycling the neurotransmitter to the presynaptic terminal. GlyT2 is the …
[HTML][HTML] Recent insights on principles of synaptic protein degradation
LD Cohen, NE Ziv - F1000Research, 2017 - ncbi.nlm.nih.gov
Maintaining synaptic integrity and function depends on the continuous removal and
degradation of aged or damaged proteins. Synaptic protein degradation has received …
degradation of aged or damaged proteins. Synaptic protein degradation has received …
A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome
We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
Molecular basis of the dominant negative effect of a glycine transporter 2 mutation associated with hyperekplexia
Hyperekplexia or startle disease is a rare clinical syndrome characterized by an
exaggerated startle in response to trivial tactile or acoustic stimuli. This neurological disorder …
exaggerated startle in response to trivial tactile or acoustic stimuli. This neurological disorder …
Presynaptic control of glycine transporter 2 (GlyT2) by physical and functional association with plasma membrane Ca2+-ATPase (PMCA) and Na+-Ca2+ exchanger …
Fast inhibitory glycinergic transmission occurs in spinal cord, brainstem, and retina to
modulate the processing of motor and sensory information. After synaptic vesicle fusion …
modulate the processing of motor and sensory information. After synaptic vesicle fusion …
The ubiquitination of the influenza A virus PB1-F2 protein is crucial for its biological function
I Košík, M Praznovska, M Košíková, Z Bobišová… - PLoS …, 2015 - journals.plos.org
The aim of the present study was to identify what influences the short half-life of the influenza
A virus PB1-F2 protein and whether a prolonged half-life affects the properties of this …
A virus PB1-F2 protein and whether a prolonged half-life affects the properties of this …