No gene has garnered more interest than p53 since its discovery over 40 years ago. In the
last two decades, thanks to seminal work from Uri Alon and Ghalit Lahav, p53 has defined a …

Gene regulatory networks (GRNs) play an important role in maintaining cellular function by
correctly timing key processes such as cell division and apoptosis. GRNs are known to …

Transcription is a pivotal step in gene expression yet a complex biochemical process. It
occurs often in a bursty manner, leading to cell-to-cell variability important for the cells …

Gene expression is an inherently noisy process. This noise is generally thought to be
deleterious as precise internal regulation of biochemical reactions is essential for cell growth …

Oscillations are crucial to the normal function of living organisms, across a wide variety of
biological processes. In eukaryotes, oscillatory dynamics are thought to arise from …

Glioblastoma (GBM) is the most aggressive malignant primary brain tumour with a median
overall survival of 15 months. To treat GBM, patients currently undergo a surgical resection …

Often, the time evolution of a biochemical reaction network is crucial for determining the
effects of combining multiple pharmaceuticals. Here we illustrate a mathematical framework …

One of the functions of the cell nucleus is to help regulate gene expression by controlling
molecular traffic across the nuclear envelope. Here we investigate, via stochastic simulation …