Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use
prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive …

In this nonsystematic review and opinion, including articles primarily selected from PubMed,
we examine the pharmacological and nonpharmacological treatments of neonatal …

Opioids are potent analgesics used to manage pain in both young and old, but the
increased use in the pregnant population has significant individual and societal implications …

OBJECTIVE: To explore whether the paraventricular nucleus (PVN) participates in
regulation of the anti-myocardial ischemia-reperfusion injury (MIRI) effect of …

A large amount of clinical evidence has revealed that ketamine can relieve fentanyl-induced
hyperalgesia. However, the underlying mechanism is still unclear. In the current study, a …

The rising prevalence of early-life opioid exposure has become a pressing public health
issue in the US Neonates exposed to opioids in utero are at risk of experiencing a …

This study is focused on developing tools to assess behavioral activity in neonatal mice
undergoing opioid withdrawal. Opioids are used to manage pain in both young and old, but …

Objective: Opioid dependence is a chronic complicated disorder characterized by relapse
and remission. Chronic administration of morphine causes symptoms of physical and …

Opioid dependence is defined by an aversive withdrawal syndrome upon drug cessation
that can motivate continued drug-taking, development of opioid use disorder, and precipitate …

This special issue is a tribute to our mentor, colleague and friend, Gavril W. Pasternak, MD,
PhD. Homage to the breadth and depth of his work (~ 450 publications) over a 40 career in …