The intracellular transport of organelles along an axon is crucial for the maintenance and
function of a neuron. Anterograde axonal transport has a role in supplying proteins and …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their
survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial …

Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several
neurodegenerative tauopathies including Alzheimer's disease (AD) and some …

Vigorous transport of cytoplasmic components along axons over substantial distances is
crucial for the maintenance of neuron structure and function. The transport of mitochondria …

Migration is a polarized cellular process that opposes a protrusive front edge to a retracting
trailing edge. From the front to the rear, actin-mediated forces sequentially promote cell …

Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …

Tau is a group of neuronal microtubule-associated proteins that are formed by alternative
mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain …

Organelle transport is vital for the development and maintenance of axons, in which the
distances between sites of organelle biogenesis, function, and recycling or degradation can …

Summary Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological
disorders, but its role in normal neuronal function is largely unknown. Here we show that …