T cell senescence has been recognized to play an immunosuppressive role in the aging
population and cancer patients. Strategies dedicated to preventing or reversing replicative …

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, which is associated with
profound alterations and defects in the immune system and a prevalent dependency on the …

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy characterized by a wide range of
tumor-induced alterations, which affect both the innate and adaptive arms of the immune …

Simple Summary Granzyme B (GzmB) is a potent cytotoxic molecule that is used by cytotoxic
T lymphocytes and natural killer cells to kill targeted infected or cancerous cells. Since its …

The transcription factor eomesodermin (EOMES) promotes interleukin (IL)-10 expression in
CD4+ T cells, which has been linked to immunosuppressive and cytotoxic activities. We …

The prognosis of follicular lymphoma (FL) patients is suspected to be influenced by tumor-
infiltrating regulatory T cells (Treg). The mechanism of Treg enrichment in FL and their …

Small cell lung cancer (SCLC) kills at least one person every 2 hr in the United Kingdom.
Some patients do relatively well but most have rapidly progressive disease. There is no …

Regulatory T cells (Tregs) are responsible for maintaining immune homeostasis by
controlling immune responses. They can be characterized by concomitant expression of …

Chimeric antigen receptor (CAR) T-cells have shown remarkable results in patients with B-
cell leukemia and lymphoma. However, while CAR T-cells have shown complete responses …

Acute myeloid leukemia (AML) is the most common hematological malignancy in adults,
characterized by distorted proliferation and the development of myeloid cells and their …