Drug repurposing strategies in the development of potential antifungal agents
Q Zhang, F Liu, M Zeng, Y Mao, Z Song - Applied Microbiology and …, 2021 - Springer
The morbidity and mortality caused by invasive fungal infections are increasing across the
globe due to developments in transplant surgery, the use of immunosuppressive agents …
globe due to developments in transplant surgery, the use of immunosuppressive agents …
Menadione: a platform and a target to valuable compounds synthesis
AS de Souza, RCB Ribeiro, DCS Costa… - Beilstein Journal of …, 2022 - beilstein-journals.org
Naphthoquinones are important natural or synthetic compounds belonging to the general
class of quinones. Many compounds in this class have become drugs that are on the …
class of quinones. Many compounds in this class have become drugs that are on the …
In vitro and in vivo Effect of Exogenous Farnesol Exposure Against Candida auris
The spreading of multidrug-resistant Candida auris is considered as an emerging global
health threat. The number of effective therapeutic regimens is strongly limited; therefore …
health threat. The number of effective therapeutic regimens is strongly limited; therefore …
Physiological and transcriptional responses of Candida parapsilosis to exogenous tyrosol
Tyrosol plays a key role in fungal morphogenesis and biofilm development. Also, it has a
remarkable antifungal effect at supraphysiological concentrations. However, the background …
remarkable antifungal effect at supraphysiological concentrations. However, the background …
Glucocorticoids may exacerbate fungal keratitis by increasing fungal aggressivity and inhibiting the formation of neutrophil extracellular traps
F Fan, X Huang, K Yuan, B Zhu, Y Zhao, R Hu… - Current Eye …, 2020 - Taylor & Francis
Purpose: To evaluate whether glucocorticoids affect the prognosis of fungal keratitis by
inhibiting the formation of neutrophil extracellular traps (NETs). Methods: A mouse model of …
inhibiting the formation of neutrophil extracellular traps (NETs). Methods: A mouse model of …
Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity
The respiratory pathogen, Streptococcus pneumoniae has acquired multiple-drug resistance
over the years. An attractive strategy to combat pneumococcal infection is to target cell …
over the years. An attractive strategy to combat pneumococcal infection is to target cell …
Identification of Genomewide alternative splicing events in sequential, isogenic clinical isolates of Candida albicans reveals a novel mechanism of drug resistance …
Alternative splicing (AS)—a process by which a single gene gives rise to different protein
isoforms in eukaryotes—has been implicated in many basic cellular processes, but little is …
isoforms in eukaryotes—has been implicated in many basic cellular processes, but little is …
Glutathione protects Candida albicans against horseradish volatile oil
Horseradish essential oil (HREO; a natural mixture of different isothiocyanates) had strong
fungicide effect against Candida albicans both in volatile and liquid phase. In liquid phase …
fungicide effect against Candida albicans both in volatile and liquid phase. In liquid phase …
Total transcriptome analysis of Candida auris planktonic cells exposed to tyrosol
Tyrosol, a secondary metabolite of Candida species, regulates fungal morphogenesis, and
its application may represent a novel innovative therapy against emerging multi-resistant …
its application may represent a novel innovative therapy against emerging multi-resistant …
Effects of the glucocorticoid betamethasone on the interaction of Candida albicans with human epithelial cells
Á Jakab, S Mogavero, TM Förster… - …, 2016 - microbiologyresearch.org
The glucocorticoid betamethasone (BM) is frequently employed in clinical practice because
of its anti-inflammatory and immunosuppressive properties. In this study, we investigated the …
of its anti-inflammatory and immunosuppressive properties. In this study, we investigated the …