Parkinson's disease (PD) is a common neurodegenerative disease, the pathological
features of which include the presence of Lewy bodies and the neurodegeneration of …

Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …

There are no disease-modifying treatments for adult human neurodegenerative diseases.
Here we test RNA-targeted therapies in two mouse models of spinocerebellar ataxia type 2 …

Calcium-activated potassium channels are fundamental regulators of neuronal excitability,
participating in interspike interval and spike-frequency adaptation. For large-conductance …

Electrophysiological research on mGluRs is now very extensive, and it is clear that activation
of mGluRs results in a large number of diverse cellular actions. Studies of mGluRs and on …

Midbrain dopaminergic (DA) neurons fire bursts of activity in response to sensory stimuli,
including those associated with primary reward. They are therefore conditional bursters–the …

The activation of group I metabotropic glutamate receptors (mGluRs) produces a variety of
actions that lead to alterations in excitability and synaptic transmission in the CA1 region of …

Glutamate is the primary excitatory neurotransmitter in the brain and plays critical roles in all
aspects of neuronal function. Disruption of normal glutamate transmission has been …

This article examines the functional significance of Ca2+-dependent synaptic plasticity in
relation to compromised memory function during aging. Research characterizing an age …

The primary function of the presynaptic nerve terminal is to release transmitter quanta and
thus activate the postsynaptic target cell. In almost every step leading to the release of …