Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Primary sarcopenia is a condition of reduced skeletal muscle mass and strength, reduced
agility, and increased fatigability and risk of bone fractures characteristic of aged, otherwise …

Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …

Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor
present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a …

Advanced age causes skeletal muscle to undergo deleterious changes including muscle
atrophy, fast-to-slow muscle fiber transition, and an increase in collagenous material that …

A novel infectious disease (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), was detected in December 2019 and declared as a global …

The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a
role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has …

Muscular dystrophies (MDs) are a group of genetic diseases characterized by progressive
muscle wasting associated to oxidative stress and persistent inflammation. It is essential to …

S100B is a calcium-binding protein mainly expressed by astrocytes, but also localized in
other definite neural and extra-neural cell types. While its presence in biological fluids is …

Extracellular matrix (ECM) is an extracellular tissue structure that, in addition to mechanical
support to the cell, is involved in regulation of many cellular processes, including chemical …