Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges

A Mushtaq, U Azam, S Mehreen, MM Naseer - European journal of …, 2023 - Elsevier
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

B Suliphuldevara Mathada… - …, 2023 - Wiley Online Library
Heterocycles are a privileged motif that appears as a momentous objective in medicinal
chemistry. An important class of compounds for drug discovery and design is indole and its …

Synthesis and biological evaluation of indole derivatives containing thiazolidine-2, 4-dione as α-glucosidase inhibitors with antidiabetic activity

C Hu, B Liang, J Sun, J Li, Z Xiong, SH Wang… - European Journal of …, 2024 - Elsevier
In order to develop potential α-glucosidase inhibitors with antidiabetic activity, twenty-six
indole derivatives containing thiazolidine-2, 4-dione were synthesized. All compounds …

Evaluation of synthetic 2-aryl quinoxaline derivatives as α-amylase, α-glucosidase, acetylcholinesterase, and butyrylcholinesterase inhibitors

S Hameed, KM Khan, P Taslimi, U Salar… - International Journal of …, 2022 - Elsevier
Variety of 2-aryl quinoxaline derivatives 1–23 were synthesized in good yields, by reacting
1, 2-phenylenediamine with varyingly substituted phenacyl bromides in the presence of …

Recent advances of α-glucosidase inhibitors: A comprehensive review

N Agrawal, M Sharma, S Singh… - Current topics in …, 2022 - ingentaconnect.com
Background: Diabetes mellitus (DM) is a critical health issue prevailing in nearly half a
billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is …

[HTML][HTML] Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery—An Updated Review on Their Multifaceted Therapeutic Applications (2020–2024)

X Mo, DP Rao, K Kaur, R Hassan, AS Abdel-Samea… - Molecules, 2024 - mdpi.com
Indole derivatives have become an important class of compounds in medicinal chemistry,
recognized for their wide-ranging biological activities and therapeutic potential. This review …

[HTML][HTML] 2-methylindole analogs as cholinesterases and glutathione S-transferase inhibitors: Synthesis, biological evaluation, molecular docking, and pharmacokinetic …

A Cetin, E Bursal, F Türkan - Arabian Journal of Chemistry, 2021 - Elsevier
In this study, we aimed to (i) synthesize new 2-methylindole analogs containing various
amino structures, pyrrolidine, piperidine, morpholine, and substituted phenyl groups through …

Design, synthesis, in vitro, and in silico anti-α-glucosidase assays of N-phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives as new anti-diabetic agents

MH Sayahi, S Zareei, M Halimi, M Alikhani… - Scientific Reports, 2024 - nature.com
In this work, a novel series of N-phenylacetamide-1, 2, 3-triazole-indole-2-carboxamide
derivatives 5a–n were designed by consideration of the potent α-glucosidase inhibitors …

Chemistry of 3-cyanoacetyl indoles: synthesis, reactions and applications: a recent update

A Olyaei, M Sadeghpour - RSC advances, 2023 - pubs.rsc.org
Indole is a significant nitrogen-based heterocycle with particular importance in the synthesis
of heterocyclic scaffolds. Indole based compounds have been recently attracting much …

Isatin thiazoles as antidiabetic: Synthesis, in vitro enzyme inhibitory activities, kinetics, and in silico studies

M Solangi, Kanwal, KM Khan… - Archiv der …, 2022 - Wiley Online Library
Diabetes mellitus is one of the most prevalent diseases nowadays. Several marketed drugs
are available for the cure and treatment of diabetes, but there is still a dire need of …