Genetics, epigenetics and autoimmunity constitute a Bermuda triangle for the pathogenesis of rheumatoid arthritis

S Srivastava, M Rasool - Life Sciences, 2024 - Elsevier
Rheumatoid arthritis (RA), a multigene disorder with a heritability rate of 60%, is
characterized by persistent pain, synovial hyperplasia, and cartilage and bone destruction …

Peptidylarginine deiminase (PAD): A promising target for chronic diseases treatment

P Mansouri, P Mansouri, E Behmard… - International Journal of …, 2024 - Elsevier
In 1958, the presence of citrulline in the structure of the proteins was discovered for the first
time. Several years later they found that Arginine converted to citrulline during a post …

[HTML][HTML] Ревматоидный артрит как клинико-иммунологический синдром: фокус на серонегативный субтип заболевания

ЕЛ Насонов, АС Авдеева… - Научно-практическая …, 2023 - cyberleninka.ru
Ревматоидный артрит (РА)-наиболее частое иммуновоспалительное (аутоиммунное)
ревматическое заболевание (ИВРЗ), проявляющийся хроническим эрозивным …

[HTML][HTML] Do cytokines play a role in the transition from acute to chronic musculoskeletal pain?

E Andrea, S Hans-Georg - Pharmacological Research, 2025 - Elsevier
Musculoskeletal pain has a high prevalence of transition to chronic pain and/or persistence
as chronic pain for years or even a lifetime. Possible mechanisms for the development of …

Immunophenotypic Landscape of synovial tissue in rheumatoid arthritis: Insights from ACPA status

JB Li, PC Liu, YP Huang, Y Wang, J Zhao, ZF Xiong… - Heliyon, 2024 - cell.com
Objective To examine the clinical features and synovial pathologies in rheumatoid arthritis
(RA) patients across varying titers of circulating anti-citrullinated protein antibodies (ACPA) …

Identification of circulating autoantibodies to non-modified proteins associated with ACPA status in early rheumatoid arthritis

L Lourido, V Joshua, M Hansson, R Sjöberg… - …, 2024 - academic.oup.com
Objective The objective of this study was to discover autoantibodies to non-modified proteins
associated with the presence/absence of ACPAs in RA. Methods The autoantibody …

类风湿关节炎血清总免疫复合物诱导破骨细胞分化引起骨质疏松的因素分析

周二叶, 曾克勤, 武剑, 任田, 何觅春 - 中国组织工程研究, 2024 - cjter.com
类风湿关节炎血清总免疫复合物诱导破骨细胞分化引起骨质疏松的因素分析 Page 1 5606|中国
组织工程研究|第28卷|第35期|2024年12月 中国组织工程研究 Chinese Journal of Tissue …

[HTML][HTML] Unlocking the Future: New Biologic Therapies for Rheumatoid Arthritis

SJ Patil, VM Thorat, AA Koparde, SD Bhinge… - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to joint destruction
and functional disability. Traditional treatments, including disease-modifying antirheumatic …

Th17 cells with a pathogenic signature in joints of ZAP-70 mutant arthritic mice harbor unique TCR repertoires that share features with WT Tregs

MA Llamas-Covarrubias, A Tanaka, M Loza, D Diez… - bioRxiv, 2024 - biorxiv.org
Autoimmune diseases such as rheumatoid arthritis (RA) represent a significant source of
worldwide morbidity and disability. Despite extensive research, the molecular mechanisms …

Osteoclast differentiation induced by total immune complex in serum of patients with rheumatoid arthritis leads to osteoporosis and its factors analysis

E Zhou, K Zeng, J Wu, T Ren, M He - Chinese Journal of Tissue …, 2024 - cjter.com
BACKGROUND: The incidence of osteoporosis significantly increases in the patients with
rheumatoid arthritis, and it remains unclear whether the presence of a large number of …