Prediction and targeting of GPCR oligomer interfaces
CAV Barreto, SJ Baptista, AJ Preto… - Progress in molecular …, 2020 - Elsevier
GPCR oligomerization has emerged as a hot topic in the GPCR field in the last years.
Receptors that are part of these oligomers can influence each other's function, although it is …
Receptors that are part of these oligomers can influence each other's function, although it is …
Epstein-Barr virus-infected nasopharyngeal carcinoma therapeutics: oncoprotein targets and clinical implications
Nasopharyngeal carcinoma (NPC) is a distinctive epithelial cancer closely associated with
Epstein-Barr Virus (EBV) infection, posing significant challenges in diagnosis and treatment …
Epstein-Barr Virus (EBV) infection, posing significant challenges in diagnosis and treatment …
De novo-designed transmembrane proteins bind and regulate a cytokine receptor
Transmembrane (TM) domains as simple as a single span can perform complex biological
functions using entirely lipid-embedded chemical features. Computational design has the …
functions using entirely lipid-embedded chemical features. Computational design has the …
[HTML][HTML] Oligomerization analysis as a tool to elucidate the mechanism of EBV latent membrane protein 1 inhibition by pentamidine
Abstract Latent membrane protein 1 (LMP1) is a gene product of the Epstein-Barr virus
(EBV), a widely spread virus present in 90–95% of the world's population. EBV can lead to …
(EBV), a widely spread virus present in 90–95% of the world's population. EBV can lead to …
Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology
M Mravic, L He, H Kratochvil, H Hu, SE Nick, W Bai… - bioRxiv, 2023 - biorxiv.org
Transmembrane (TM) domains as simple as a single span can perform complex biological
functions using entirely lipid-embedded chemical features. Computational design has …
functions using entirely lipid-embedded chemical features. Computational design has …
Where to next in the evolution of in silico design of modulators targeting protein–protein interactions?
Protein–protein interactions (PPIs) play a crucial role in essential cellular functions including
cell division, transmembrane signaling, and protein recognition. Abnormal PPIs have been …
cell division, transmembrane signaling, and protein recognition. Abnormal PPIs have been …
In silico strategy to model LMP1 of Epstein–Barr virus protein
DSDA Salam, S San Hwang, F Wang… - 2023 IEEE …, 2023 - ieeexplore.ieee.org
Epstein-Barr Virus (EBV) is among the world's most common and best-studied viruses. The
latent membrane protein 1 (LMP1) is an essential latent EBV gene variation. LMP1 is an …
latent membrane protein 1 (LMP1) is an essential latent EBV gene variation. LMP1 is an …
抑制EB 病毒阳性弥漫性大B 细胞淋巴瘤增殖的抗TMD5 单克隆抗体的筛选和效果评价
涂小云， 熊玉红， 邓爱花， 孙春枝， 刘阳… - 广西医科大学 …, 2023 - journal.gxmu.edu.cn
目的: 筛选抗爱泼斯坦—巴尔病毒(EBV) 潜伏期膜蛋白-1 中跨膜结构域5 (TMD5)
单克隆抗体并评价其抑制EB 病毒阳性弥漫性大B 细胞淋巴瘤(DLBCL) 的效果. 方法 …
单克隆抗体并评价其抑制EB 病毒阳性弥漫性大B 细胞淋巴瘤(DLBCL) 的效果. 方法 …
靶向EBV 潜伏膜蛋白1 的单克隆抗体促进HIV 相关EBV 阳性伯基特淋巴瘤细胞凋亡的分子机制
涂小云， 陈宇， 熊玉红， 邓爱花， 孙春枝… - 医学分子生物学 …, 2023 - tjqk.magtech.com.cn
目的制备和筛选抑制伯基特淋巴瘤(Burkitt lymphoma, BL) 的抗EBV 潜伏膜蛋白1
(latentmembrane protein-1, LMP1) 单克隆抗体. 方法人工合成EBV 潜伏膜蛋白1 …
(latentmembrane protein-1, LMP1) 单克隆抗体. 方法人工合成EBV 潜伏膜蛋白1 …
Targeting the transmembrane domain 5 of latent membrane protein 1 using small molecule modulators
Protein-protein interactions (PPIs) play a critical role in living cells and represent promising
targets for the drug discovery and life sciences communities. However, lateral …
targets for the drug discovery and life sciences communities. However, lateral …