Recognition of the DNA minor groove by pyrrole-imidazole polyamides - ScienceDirect Skip
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Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism …

The extremities of eukaryotic chromosomes are called telomeres. They have a structure
unlike the bulk of the chromosome, which allows the cell DNA repair machinery to …

Chromosome ends are protected from degradation by the presence of the highly repetitive
hexanucleotide sequence of TTAGGG and associated proteins. These so‐called telomeric …

This review analyses the literature concerning non-fluorescent and fluorescent probes for
nucleic acid imaging in fixed and living cells from the point of view of their suitability for …

Methods for the fluorescent detection of specific sequences of double strand DNA in
homogeneous solution may be useful in the field of human genetics. A series of hairpin …

A pivotal step forward in chemical approaches to controlling gene expression is the
development of sequence‐specific DNA‐binding molecules that can enter live cells and …

The cellular uptake and localization properties of DNA binding N-methylpyrrole/N-
methylimidazole polyamide–dye conjugates in a variety of living cells have been examined …

Methodologies to detect DNA sequences with high sensitivity and specificity have
tremendous potential as molecular diagnostic agents. Most current methods exploit the …

Abstract Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …