Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory

A Guskjolen, MS Cembrowski - Molecular psychiatry, 2023 - nature.com
Tremendous strides have been made in our understanding of the neurobiological substrates
of memory–the so-called memory “engram”. Here, we integrate recent progress in the …

The hippocampus and related neocortical structures in memory transformation

MJ Sekeres, G Winocur, M Moscovitch - Neuroscience letters, 2018 - Elsevier
Episodic memories are multifaceted and malleable, capable of being transformed with time
and experience at both the neural level and psychological level. At the neural level, episodic …

Engrams and circuits crucial for systems consolidation of a memory

T Kitamura, SK Ogawa, DS Roy, T Okuyama… - Science, 2017 - science.org
Episodic memories initially require rapid synaptic plasticity within the hippocampus for their
formation and are gradually consolidated in neocortical networks for permanent storage …

The role of medial prefrontal cortex in memory and decision making

DR Euston, AJ Gruber, BL McNaughton - Neuron, 2012 - cell.com
Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making.
Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet …

A temporal shift in the circuits mediating retrieval of fear memory

FH Do-Monte, K Quinones-Laracuente, GJ Quirk - Nature, 2015 - nature.com
Fear memories allow animals to avoid danger, thereby increasing their chances of survival.
Fear memories can be retrieved long after learning,, but little is known about how retrieval …

Structural components of synaptic plasticity and memory consolidation

CH Bailey, ER Kandel… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the
mammalian hippocampus are associated with remodeling and growth of preexisting …

Schema-dependent gene activation and memory encoding in neocortex

D Tse, T Takeuchi, M Kakeyama, Y Kajii, H Okuno… - Science, 2011 - science.org
When new learning occurs against the background of established prior knowledge, relevant
new information can be assimilated into a schema and thereby expand the knowledge base …

Systems consolidation induces multiple memory engrams for a flexible recall strategy in observational fear memory in male mice

JI Terranova, J Yokose, H Osanai, SK Ogawa… - Nature …, 2023 - nature.com
Observers learn to fear the context in which they witnessed a demonstrator's aversive
experience, called observational contextual fear conditioning (CFC). The neural …

The cognitive neuroscience of human memory since HM

LR Squire, JT Wixted - Annual review of neuroscience, 2011 - annualreviews.org
Work with patient HM, beginning in the 1950s, established key principles about the
organization of memory that inspired decades of experimental work. Since HM, the study of …

Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation

F Xia, BA Richards, MM Tran, SA Josselyn… - Elife, 2017 - elifesciences.org
Following learning, increased coupling between spindle oscillations in the medial prefrontal
cortex (mPFC) and ripple oscillations in the hippocampus is thought to underlie memory …