Metalloproteinases between History, Health, Disease, and the Complex Dimension of Social Determinants of Health
Metalloproteinases (MPs) belong to the superfamily of zinc endopeptidases, which are
called metzincins. Three families of MPs have been studied in healthy and diseased …
called metzincins. Three families of MPs have been studied in healthy and diseased …
Single-cell assessment of trophoblast stem cell-based organoids as human placenta-modeling platforms
MJ Shannon, GL McNeill, B Koksal, J Baltayeva… - bioRxiv, 2022 - biorxiv.org
The recent discovery of human trophoblast stem cells (hTSC) and techniques allowing for
trophoblast organoid (TOrg) culture have established promising approaches for studying …
trophoblast organoid (TOrg) culture have established promising approaches for studying …
Unravelling human placental (patho-) physiology at the epigenetic and transcriptome level
A Samara, A Khalil - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
One of the paradoxes of human development lies in its temporary dependence on an
extracorporeal organ, the placenta. The placenta is this complex entity that interfaces with …
extracorporeal organ, the placenta. The placenta is this complex entity that interfaces with …
ADAM, ADAMTS and astacin proteases: Challenges and breakthroughs in the-Omics era-Volume II
HF Kwok, K Yamamoto, R de Groot… - Frontiers in molecular …, 2023 - frontiersin.org
ADAMs (A Disintegrin and Metalloproteinases), ADAMTS (A Disintegrin and
Metalloproteinase with Thrombospondin motifs) and astacins are three sub-families of …
Metalloproteinase with Thrombospondin motifs) and astacins are three sub-families of …
RNA sequencing reveals the developmental onset of autosomal gene expression differences in male and female extravillous trophoblasts
MJ Shannon, AG Beristain - bioRxiv, 2024 - biorxiv.org
Background: The human placenta is an essential organ for fetal development and
pregnancy success. Across gestation, blastocyst-derived trophoblasts facilitate the major …
pregnancy success. Across gestation, blastocyst-derived trophoblasts facilitate the major …