The carboxylic acid functional group can be an important constituent of a pharmacophore,
however, the presence of this moiety can also be responsible for significant drawbacks …

Alzheimer's disease (AD), the most common cause of dementia, is a progressive
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …

Shorter reaction times, higher product yields, and enhanced selectivity are some of the
advantages microwave heating has over conventional methods, causing its use to transition …

D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …

D-amino acid oxidase (DAO) is a flavoenzyme that metabolizes certain D-amino acids,
notably the endogenous N-methyl D-aspartate receptor (NMDAR) co-agonist, D-serine. As …

d-Amino acid oxidase (DAAO) is a well-known flavoenzyme that catalyzes the oxygen-
dependent oxidative deamination of amino acid D-isomers with absolute stereospecificity …

Schizophrenia is a severe mental illness that affects~ 1% of the world's population. It is
clinically characterized by positive, negative, and cognitive symptoms. Currently available …

Hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has been implicated in the
pathophysiology of schizophrenia. The NMDAR contains a d-serine/glycine site on the NR1 …

Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …

The glutamate neurotransmitter system is one of the major candidate pathways for the
pathophysiology of schizophrenia, and increased understanding of the pharmacology …