The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

Lysine L-lactylation [K (L-la)] is a newly discovered histone mark stimulated under conditions
of high glycolysis, such as the Warburg effect. K (L-la) is associated with functions that are …

Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate
environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment …

Immune cells function in diverse metabolic environments. Tissues with low glucose and high
lactate concentrations, such as the intestinal tract or ischemic tissues, frequently require …

Several lines of evidence suggest that brain function and behaviour are influenced by
microbial metabolites. Key products of the microbiota are short-chain fatty acids (SCFAs) …

L‐lactate is a key metabolite indicative of physiological states, glycolysis pathways, and
various diseases such as sepsis, heart attack, lactate acidosis, and cancer. Detection of …

Myalgic encephalomyelitis (ME) or Chronic Fatigue Syndrome (CFS) is a neglected,
debilitating multi-systemic disease without diagnostic marker or therapy. Despite evidence …

The composition and structure of the pregnancy vaginal microbiome may influence
susceptibility to adverse pregnancy outcomes. Studies on the pregnant vaginal microbiome …

During an inflammatory process, shift in the cellular metabolism associated with an increase
in extracellular acidification are well-known features. This pH drop in the inflamed tissue is …