Recent advances of pyrazole-containing derivatives as anti-tubercular agents
Z Xu, C Gao, QC Ren, XF Song, LS Feng… - European journal of …, 2017 - Elsevier
One-third of the world's population infected tuberculosis (TB), and more than 1 million
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …
Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders
Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
[HTML][HTML] Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular …
In the present work, a small library of novel pyrazolinyl-acyl thiourea (5a–j) was designed
and synthesized through a multistep sequence and the synthesized compounds were …
and synthesized through a multistep sequence and the synthesized compounds were …
Recent progress on pyrazole scaffold‐based antimycobacterial agents
New and reemerging infectious diseases will continue to pose serious global health threats
well into the 21st century and according to the World Health Organization report, these are …
well into the 21st century and according to the World Health Organization report, these are …
Synthesis, Characterisation, and In Vitro Anticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase
In search of potential therapeutics for cancer, we described herein the synthesis,
characterization, and in vitro anticancer activity of a novel series of curcumin analogues. The …
characterization, and in vitro anticancer activity of a novel series of curcumin analogues. The …
Discovery of novel antitubercular 1, 5-dimethyl-2-phenyl-4-([5-(arylamino)-1, 3, 4-oxadiazol-2-yl] methylamino)-1, 2-dihydro-3H-pyrazol-3-one analogues
MJ Ahsan, JG Samy, CB Jain, KR Dutt… - Bioorganic & medicinal …, 2012 - Elsevier
In search of potential therapeutics for tuberculosis, we describe herewith the synthesis,
characterization and antimycobacterial activity of 1, 5-dimethyl-2-phenyl-4-([5-(arylamino)-1 …
characterization and antimycobacterial activity of 1, 5-dimethyl-2-phenyl-4-([5-(arylamino)-1 …
An overview on the synthetic and medicinal perspectives of indenopyrazoles
Indenopyrazole is emerging as one of the most promising and privileged scaffold in
medicinal chemistry. This scaffold have been investigated for the development of novel …
medicinal chemistry. This scaffold have been investigated for the development of novel …
[HTML][HTML] NSC 18725, a Pyrazole Derivative Inhibits Growth of Intracellular Mycobacterium tuberculosis by Induction of Autophagy
The increasing incident rates of drug-resistant tuberculosis (DR-TB) is a global health
concern and has been further complicated by the emergence of extensive and total drug …
concern and has been further complicated by the emergence of extensive and total drug …
Chalcone and pyrazoline derivatives of dehydroacetic acid as digestive enzyme effectors and In silico studies
In the present work, chalcone and pyrazoline derivatives of dehydroacetic acid have been
synthesized using methanol as solvent. All the synthesized compounds were characterized …
synthesized using methanol as solvent. All the synthesized compounds were characterized …
Methyl 3-((6-Methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and …
H Minegishi, Y Futamura, S Fukashiro… - Journal of Medicinal …, 2015 - ACS Publications
A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl
isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1, 4 …
isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1, 4 …