Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Silent information Regulators (SIRT1) gene stimulates antioxidants' expression, repairs cells
damaged by oxidative stress (OS), and prevents the cells' dysfunction. In particular, the role …

STUDY QUESTION Does resveratrol counteract age-associated infertility in a mouse model
of reproductive aging? SUMMARY ANSWER Long-term-oral administration of resveratrol …

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Objective To analyze the potential beneficial effects and mechanisms of action of resveratrol
on the maturation of bovine oocytes that were incubated in different concentrations of …

Resveratrol is one of the most investigated natural polyphenolic compounds and is
contained in more than 70 types of plants and in red wine. The widespread interest in this …

In search for strategies aimed at preventing oxidative threat to female fertility, a possible role
of sirtuins has emerged. Sirtuins (silent information regulator 2 (Sir2) proteins), NAD+ …

This study hypothesized that resveratrol, a silencing information regulator 1 (SIRT1)
activator, would counteract the inflammatory signaling associated with radiotherapy-induced …