Chemical warfare agents constitute one of the greatest threats in the modern world. Among
them, the neurotoxic agents are of special interest due to their high lethality and danger …

Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was
published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater …

Sažetak Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents
(NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter …

After more than 70 years of considerable efforts, research on medical defense against nerve
agents has come to a standstill. Major progress in medical countermeasures was achieved …

Prophylactic approaches against intoxication with organophosphates (OP)/nerve agents can
be based on following principles: keeping acetylcholinesterase (AChE), the key enzyme for …

Nerve agents are acetylcholinesterase inhibitors, exposure to which causes brain damage,
primarily by inducing intense seizure activity. Knowledge of the brain regions that are most …

Nerve agents are deadly threats to military and civilian populations around the world. Nerve
agents cause toxicity to peripheral and central sites through the irreversible inhibition of …

Exposure to nerve agents and other organophosphorus acetylcholinesterases used in
industry and agriculture can cause death, or brain damage, producing long-term cognitive …

The carbamate pyridostigmine bromide (PB) is the only fielded pharmacological prophylaxis
for military use against nerve agents. Previous studies have shown differences in the PB …