Challenges and Opportunities in the Clinical Translation of High-Resolution Spatial Transcriptomics

TM Pentimalli, N Karaiskos… - Annual Review of …, 2024 - annualreviews.org
Pathology has always been fueled by technological advances. Histology powered the study
of tissue architecture at single-cell resolution and remains a cornerstone of clinical …

Integrating spatially-resolved transcriptomics data across tissues and individuals: challenges and opportunities

B Guo, W Ling, SH Kwon, P Panwar, S Ghazanfar… - ArXiv, 2024 - pmc.ncbi.nlm.nih.gov
Advances in spatially-resolved transcriptomics (SRT) technologies have propelled the
development of new computational analysis methods to unlock biological insights. As the …

[HTML][HTML] Scoping Review: Methods and Applications of Spatial Transcriptomics in Tumor Research

K Maciejewski, P Czerwinska - Cancers, 2024 - mdpi.com
Simple Summary Spatial transcriptomics is a technique of measuring gene expression with
spatial resolution on a tissue slide, which is especially useful in cancer research. This …

Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistance

RH Boe, CG Triandafillou, R Lazcano, JA Wargo… - …, 2024 - pmc.ncbi.nlm.nih.gov
Resistance to cancer therapy is driven by both cell-intrinsic and microenvironmental factors.
Previous work has revealed that multiple resistant cell fates emerge in melanoma following …

Next‐generation spatial transcriptomics: unleashing the power to gear up translational oncology

N Wang, W Hong, Y Wu, ZS Chen, M Bai, W Wang… - MedComm, 2024 - Wiley Online Library
The growing advances in spatial transcriptomics (ST) stand as the new frontier bringing
unprecedented influences in the realm of translational oncology. This has triggered systemic …

Homebuilt Imaging-Based Spatial Transcriptomics: Tertiary Lymphoid Structures as a Case Example

T Defard, A Desrentes, C Fouillade… - … Structures: Methods and …, 2024 - Springer
Spatial transcriptomics methods provide insight into the cellular heterogeneity and spatial
architecture of complex, multicellular systems. Combining molecular and spatial information …

A DIY guide for image-based spatial transcriptomic: TLS as a case example

T Defard, A Desrentes, C Fouillade, F Mueller - bioRxiv, 2024 - biorxiv.org
Spatial RNA profiling methods provide insight to the cellular heterogeneity and spatial
architecture of complex, multi-cellular systems. Combining molecular and spatial information …

ResolVI-addressing noise and bias in spatial transcriptomics

C Ergen, N Yosef - bioRxiv, 2025 - biorxiv.org
Technologies for estimating RNA expression at high throughput, in intact tissue slices, and
with high spatial resolution (spatial transcriptomics; ST) shed new light on how cells …