Bee venom: Overview of main compounds and bioactivities for therapeutic interests

R Wehbe, J Frangieh, M Rima, D El Obeid, JM Sabatier… - Molecules, 2019 - mdpi.com
Apitherapy is an alternate therapy that relies on the usage of honeybee products, most
importantly bee venom for the treatment of many human diseases. The venom can be …

Harnessing the power of bee venom for therapeutic and regenerative medical applications: an updated review

KM Sadek, NA Shib, ES Taher, F Rashed… - Frontiers in …, 2024 - frontiersin.org
Honeybees have been helpful insects since ancient centuries, and this benefit is not limited
to being a honey producer only. After the bee stings a person, pain, and swelling occur in …

Actions of metformin in the brain: a new perspective of metformin treatments in related neurological disorders

N Li, T Zhou, E Fei - International Journal of Molecular Sciences, 2022 - mdpi.com
Metformin is a first-line drug for treating type 2 diabetes mellitus (T2DM) and one of the most
commonly prescribed drugs in the world. Besides its hypoglycemic effects, metformin also …

Evidence of disturbed insulin signaling in animal models of Alzheimer's disease

SS Alves, G Servilha-Menezes, L Rossi… - Neuroscience & …, 2023 - Elsevier
Since glucose reuptake by neurons is mostly independent of insulin, it has been an
intriguing question whether insulin has or not any roles in the brain. Consequently, the …

Neuroprotective potential of antihyperglycemic drug metformin in streptozocin-induced rat model of sporadic Alzheimer's disease

V Pilipenko, K Narbute, J Pupure, IK Langrate… - European Journal of …, 2020 - Elsevier
The earliest hallmarks of sporadic Alzheimer's disease (sAD) are impaired glucose
metabolism, chronic neuroinflammation, diminished synaptic plasticity and subsequent …

Metformin a potential pharmacological strategy in late onset Alzheimer's disease treatment

SR Poor, M Ettcheto, A Cano, E Sanchez-Lopez… - Pharmaceuticals, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the most devastating brain disorders. Currently, there are
no effective treatments to stop the disease progression and it is becoming a major public …

Rosiridin attenuates scopolamine-induced cognitive impairments in rats via inhibition of oxidative and nitrative stress leaded caspase-3/9 and TNF-α signaling …

M Afzal, SI Alzarea, KS Alharbi, AI Alzarea, SK Alenezi… - Molecules, 2022 - mdpi.com
Aim: A monoterpene and bioactive component of the plant Rhodiola rosea (R. rosea),
rosiridin has beneficial effects on the human central nervous system and enhances brain …

Exploring the dual character of metformin in Alzheimer's disease

P Ning, A Luo, X Mu, Y Xu, T Li - Neuropharmacology, 2022 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease, which results in
dementia typically in the elderly. The disease is mainly characterized by the deposition of …

The effect of metformin on cognitive function: a systematic review and meta-analysis

O Tabatabaei Malazy, F Bandarian… - Journal of …, 2022 - journals.sagepub.com
Most people are familiar with metformin as a diabetic treatment option. Different positive
benefits have been found for it, in addition to its anti-diabetes properties. Cognitive function …

[HTML][HTML] A review on role of metformin as a potential drug for epilepsy treatment and modulation of epileptogenesis

R Singh, SC Sarangi, S Singh, M Tripathi - Seizure, 2022 - Elsevier
Background Available anti-seizure medications (ASMs) target the symptomatology of the
disease rather than any significant disease/epileptogenesis modifying actions. There are …