Highlights•Advances in the combination of the CuAAC reaction with direct screening.•Before
library assembly, the bioisosteric potential of 1, 2, 3-triazole should be confirmed.•The …

The completion of the human genome sequencing project has provided a wealth of new
information regarding the genomic blueprint of the cell. Although, to date, there are roughly …

Click chemistry provides extremely selective and orthogonal reactions that proceed with
high efficiency and under a variety of mild conditions, the most common example being the …

Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and
resource-intensive process. Lack of automation and reliance on skilled medicinal chemists …

A molecular hybridization approach is an emerging structural modification tool to design
new molecules with improved pharmacophoric properties. In this study, 1, 2, 3-triazole …

To find HDAC8-selective inhibitors, we designed a library of HDAC inhibitor candidates,
each containing a zinc-binding group that coordinates with the active-site zinc ion, linked via …

To find histone deacetylase 3 (HDAC3)-selective inhibitors, a series of 504 candidates was
assembled using “click chemistry”, by reacting nine alkynes bearing a zinc-binding group …

CuI-catalysed azide alkyne 1, 3-dipolar cycloaddition (CuAAC)'click chemistry'was used to
assemble a library of 21 α-d-and β-d-glucopyranosyl triazoles, which were assessed as …

Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates
nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). NNMT overexpression …

Abstract Poly (ADP‐ribose) polymerases (PARPs) are key enzymes in a variety of cellular
processes. Most small‐molecule PARP inhibitors developed to date have been against …