Functional Annotation of Animal Genomes (FAANG): current achievements and roadmap
Functional annotation of genomes is a prerequisite for contemporary basic and applied
genomic research, yet farmed animal genomics is deficient in such annotation. To address …
genomic research, yet farmed animal genomics is deficient in such annotation. To address …
Recent advances in CRISPR/Cas9-mediated knock-ins in mammalian cells
M Banan - Journal of biotechnology, 2020 - Elsevier
Since its inception, the CRISPR/Cas9 technology has been widely utilized for the targeted
insertion of donor DNAs into mammalian genomes. A shortcoming with the earlier knock-in …
insertion of donor DNAs into mammalian genomes. A shortcoming with the earlier knock-in …
H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
Chromatin and cancer: implications of disrupted chromatin organization in tumorigenesis and its diversification
P Sehgal, P Chaturvedi - Cancers, 2023 - mdpi.com
Simple Summary Human DNA is~ 2 m long, but is efficiently packaged in cell nucleus that is
a million times smaller. The concerted action of several enzymes enables this packaging …
a million times smaller. The concerted action of several enzymes enables this packaging …
Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice
J McCallum-Loudeac, E Moody… - Human molecular …, 2024 - academic.oup.com
Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis, in which spinal
curvature develops in adolescence, and 90% of patients are female. Scoliosis is a …
curvature develops in adolescence, and 90% of patients are female. Scoliosis is a …
Expression and hydroxyurea-triggered induction of EGFP upon CRISPR/Cas9-mediated integration into the γ-globin gene of K562 cells
Objective To knock-in an EGFP cassette into the γ-globin genes of K562 cells via
CRISPR/Cas9, and to assess expression and hydroxyurea (HU)-mediated induction of the …
CRISPR/Cas9, and to assess expression and hydroxyurea (HU)-mediated induction of the …
[PDF][PDF] Insights into spinal cord biology and its contributions to adolescent idiopathic scoliosis: from GWAS to animal models
JAD McCallum-Loudeac - University of Otago, Dunedin, 2021 - ourarchive.otago.ac.nz
The aim of this thesis was to investigate the relationship between the spinal cord, adolescent
idiopathic scoliosis (AIS), biological sex and a transcription factor, LBX1. AIS is a …
idiopathic scoliosis (AIS), biological sex and a transcription factor, LBX1. AIS is a …
Rearranging Natural and Engineered Genomes: From Mobile DNA to Designer Deletion Cell Lines
D Li - 2018 - search.proquest.com
All genomes in living organisms can change under the influence of internal or external
factors, and they have been repeatedly rearranged since the beginning of the life on the …
factors, and they have been repeatedly rearranged since the beginning of the life on the …
[引用][C] Expression and hydroxyurea-triggered induction of EGFP upon CRISPR/Cas9-mediated integration into the خ³-globin gene of K562 cells.
H Jafar, S Hesami, M Safi, F GhasemiMehdi Banan - 2019 - springer