Pathophysiology of diabetes: An overview
MZ Banday, AS Sameer, S Nissar - Avicenna journal of …, 2020 - thieme-connect.com
Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex
pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which …
pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which …
Monogenic diabetes: a gateway to precision medicine in diabetes
Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …
[PDF][PDF] Definition, epidemiology, and classification of diabetes in children and adolescents.
Maria E Craiga, b, Craig Jefferiesc, Dana Dabelead, Naby Baldee, Anju Sethf and Kim C
Donaghuea aInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead …
Donaghuea aInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead …
[HTML][HTML] The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study
Background Traditional genetic testing focusses on analysis of one or a few genes
according to clinical features; this approach is changing as improved sequencing methods …
according to clinical features; this approach is changing as improved sequencing methods …
New insights into KATP channel gene mutations and neonatal diabetes mellitus
The ATP-sensitive potassium channel (KATP channel) couples blood levels of glucose to
insulin secretion from pancreatic β-cells. KATP channel closure triggers a cascade of events …
insulin secretion from pancreatic β-cells. KATP channel closure triggers a cascade of events …
Type 1 diabetes onset in Lombardy region, Italy, during the COVID-19 pandemic: The double-wave occurrence
C Mameli, A Scaramuzza, M Macedoni, G Marano… - …, 2021 - thelancet.com
Abstract Background The Italian Lombardy region has been the epicenter of COVID-19
since February 2020. This study analyses the epidemiology of pediatric type 1 diabetes …
since February 2020. This study analyses the epidemiology of pediatric type 1 diabetes …
Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry
HU Irgens, J Molnes, BB Johansson, M Ringdal… - Diabetologia, 2013 - Springer
Aims/hypothesis Monogenic diabetes (MD) might be misdiagnosed as type 1 diabetes. The
prevalence of MD among children with apparent type 1 diabetes has not been established …
prevalence of MD among children with apparent type 1 diabetes has not been established …
GATA6 Mutations Cause a Broad Phenotypic Spectrum of Diabetes From Pancreatic Agenesis to Adult-Onset Diabetes Without Exocrine Insufficiency
E De Franco, C Shaw-Smith, SE Flanagan… - Diabetes, 2013 - Am Diabetes Assoc
We recently reported de novo GATA6 mutations as the most common cause of pancreatic
agenesis, accounting for 15 of 27 (56%) patients with insulin-treated neonatal diabetes and …
agenesis, accounting for 15 of 27 (56%) patients with insulin-treated neonatal diabetes and …
Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study
K Busiah, S Drunat, L Vaivre-Douret… - The lancet Diabetes & …, 2013 - thelancet.com
Background Neonatal diabetes mellitus is a rare genetic form of pancreatic β-cell
dysfunction. We compared phenotypic features and clinical outcomes according to genetic …
dysfunction. We compared phenotypic features and clinical outcomes according to genetic …
Sulfonylurea therapy benefits neurological and psychomotor functions in patients with neonatal diabetes owing to potassium channel mutations
OBJECTIVE Neonatal diabetes secondary to mutations in potassium-channel subunits is a
rare disease but constitutes a paradigm for personalized genetics-based medicine, as …
rare disease but constitutes a paradigm for personalized genetics-based medicine, as …