The complex polymicrobial composition of human gut microbiota plays a key role in health
and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal …

The gut microbiota is a complex and plastic consortium of microorganisms that are intricately
connected with human physiology. The liver is a central immunological organ that is …

Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …

Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct
strictures and progressive liver disease. Inflammatory bowel disease is usually present and …

The gut microbiome is affected by multiple factors, including genetics. In this study, we
assessed the influence of host genetics on microbial species, pathways and gene ontology …

The gut microbiota has recently evolved as a new important player in the pathophysiology of
many intestinal and extraintestinal diseases. The liver is the organ which is in closest contact …

AIM To characterize the gut bacterial microbiota of patients with primary sclerosing
cholangitis (PSC) and ulcerative colitis (UC). METHODS Stool samples were collected and …

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown
aetiology for which there are no approved therapeutic options. Patients with PSC display …

Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …

Microbial cells significantly outnumber human cells in the body, and the microbial flora at
mucosal sites are shaped by environmental factors and, less intuitively, act on host immune …