The large majority of variants identified by GWAS are non-coding, motivating detailed
characterization of the function of non-coding variants. Experimental methods to assess …

Single-nucleotide polymorphisms (SNPs) near the ERAP2 gene are associated with various
autoimmune conditions, as well as protection against lethal infections. Due to high linkage …

Background Several observational studies suggest a possible link between lipid-lowering
drugs and allergic diseases. However, inferring causality from these studies can be …

A classic population genetic prediction is that alleles experiencing directional selection
should swiftly traverse allele frequency space, leaving detectable reductions in genetic …

A classic population genetic prediction is that alleles experiencing directional selection
should swiftly traverse allele frequency space, leaving detectable reductions in genetic …

Evolutionary adaptation in humans is shaped primarily by the selection of beneficial alleles.
Classical population genetic theory predicts that alleles under selection will experience a …

Today, new technologies, such as microarrays or high-performance sequencing, are
producing more and more genomic data. This fact has brought new opportunities and …

Gene disruption has been drastically facilitated by recent genome editing tools. While the
efficiency of gene disruption in cell culture has improved, clone isolation remains routinely …