Nanocarrier based active targeting strategies against erythrocytic stage of malaria
Abstract The Global Technical Strategy for Malaria 2016–2030 aims to achieve a 90%
reduction in malaria cases, and strategic planning and execution are crucial for …
reduction in malaria cases, and strategic planning and execution are crucial for …
Active migration and passive transport of malaria parasites
Malaria parasites undergo a complex life cycle between their hosts and vectors. During this
cycle the parasites invade different types of cells, migrate across barriers, and transfer from …
cycle the parasites invade different types of cells, migrate across barriers, and transfer from …
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
Dedicated to the memory of Professors Henry G. Kunkel and Bruce Merrifield (Rockefeller
University, New York), who introduced us to the fascinating worlds of immunology and …
University, New York), who introduced us to the fascinating worlds of immunology and …
Novel approaches to identify protective malaria vaccine candidates
Efforts to develop vaccines against malaria have been the focus of substantial research
activities for decades. Several categories of candidate vaccines are currently being …
activities for decades. Several categories of candidate vaccines are currently being …
Plasmodium helical interspersed subtelomeric (PHIST) proteins, at the center of host cell remodeling
JD Warncke, I Vakonakis, HP Beck - Microbiology and Molecular …, 2016 - Am Soc Microbiol
During the asexual cycle, Plasmodium falciparum extensively remodels the human
erythrocyte to make it a suitable host cell. A large number of exported proteins facilitate this …
erythrocyte to make it a suitable host cell. A large number of exported proteins facilitate this …
Anti-Apical-Membrane-Antigen-1 Antibody Is More Effective than Anti-42-Kilodalton-Merozoite-Surface-Protein-1 Antibody in Inhibiting Plasmodium falciparum …
K Miura, H Zhou, A Diouf, SE Moretz… - Clinical and Vaccine …, 2009 - Am Soc Microbiol
ABSTRACT Apical membrane antigen 1 (AMA1) and the 42-kDa merozoite surface protein 1
(MSP142) are leading malaria vaccine candidates. Several preclinical and clinical trials …
(MSP142) are leading malaria vaccine candidates. Several preclinical and clinical trials …
Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines
DR Salamanca, M Gómez, A Camargo… - Frontiers in …, 2019 - frontiersin.org
Plasmodium falciparum malaria is a disease causing high morbidity and mortality rates
worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines …
worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines …
Hotspots in Plasmodium and RBC Receptor-Ligand Interactions: Key Pieces for Inhibiting Malarial Parasite Invasion
Protein-protein interactions (IPP) play an essential role in practically all biological
processes, including those related to microorganism invasion of their host cells. It has been …
processes, including those related to microorganism invasion of their host cells. It has been …
The origin and diversification of the merozoite surface protein 3 (msp3) multi-gene family in Plasmodium vivax and related parasites
The genus Plasmodium is a diversified group of parasites with more than 200 known
species that includes those causing malaria in humans. These parasites use numerous …
species that includes those causing malaria in humans. These parasites use numerous …
Plasmodium vivax ligand-receptor interaction: PvAMA-1 domain I contains the minimal regions for specific interaction with CD71+ reticulocytes
G Arévalo-Pinzón, M Bermúdez, D Hernández… - Scientific reports, 2017 - nature.com
The malarial parasite's invasion is complex, active and coordinated, involving many low and
high affinity interactions with receptors on target cell membrane. Proteomics analysis has …
high affinity interactions with receptors on target cell membrane. Proteomics analysis has …