The cyclic AMP response element binding (CREB) protein has pleiotropic activities in
physiologic processes. Due to its central position downstream of many growth signaling …

Local acidification is a common feature of many disease processes such as inflammation,
infarction, or solid tumor growth. Acidic pH is not merely a sequela of disease but contributes …

This paper discusses the evidence for the role of CREB in neural stem/progenitor cell
(NSPC) function and oncogenesis and how these functions may be important for the …

Hematologic malignancies are a large and heterogeneous group of neoplasms
characterized by complex pathogenetic mechanisms. The abnormal regulation of epigenetic …

Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease
(disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells …

Abstract cAMP response element binding protein (CREB) is frequently overexpressed in
acute myeloid leukemia (AML) and acts as a proto-oncogene; however, it is still debated …

Gene expression is modulated through the integration of many regulatory elements and their
associated transcription factors (TFs). TFs bind to specific DNA sequences and either …

MicroRNA-34b down-regulation in acute myeloid leukemia was previously shown to induce
CREB overexpression, thereby causing leukemia proliferation in vitro and in vivo. The role of …

Patients with acute myeloid leukemia (AML) carrying high-risk genetic lesions or high
residual disease levels after therapy are particularly exposed to the risk of relapse. Here, we …

The cAMP response element‐binding protein (CREB) is a nuclear transcription factor
downstream of cell surface receptors and mitogens that is critical for normal and neoplastic …