Human replication protein A (RPA), a heterotrimeric protein complex, was originally defined
as a eukaryotic single‐stranded DNA binding (SSB) protein essential for the in vitro …

Defects in cellular DNA metabolism have a direct role in many human disease processes.
Impaired responses to DNA damage and basal DNA repair have been implicated as causal …

Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much
progress has been made on elucidating critical roles for RPA in other DNA metabolic …

ATR is an essential kinase activated in response to DNA-replication stress, with a known
target being the RPA2 subunit of human replication protein A (RPA). We find that S33-RPA2 …

Mammalian replication protein A (RPA) undergoes DNA damage-dependent
phosphorylation at numerous sites on the N terminus of the RPA2 subunit. To understand …

The heterotrimeric DNA-binding protein, replication protein A (RPA), consists of 70-, 34-, and
14-kDa subunits and is involved in maintaining genomic stability by playing key roles in …

Abstract Replication Protein A (RPA) is a heterotrimeric protein complex that binds single-
stranded DNA. In plants, multiple genes encode the three RPA subunits (RPA1, RPA2 and …

Replication protein A (RPA) is a single‐stranded DNA (ssDNA) binding protein involved in
various processes, including nucleotide excision repair and DNA replication. The 32 kDa …

The tumor suppressor protein p53 is emerging as a central regulator of homologous
recombination (HR) processes and DNA replication. P53 may downregulate HR through …

Replication protein A (RPA, also known as human single-stranded DNA-binding protein) is a
trimeric, multifunctional protein complex involved in DNA replication, DNA repair, and …