Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are
the end product of a cell lineage which has to undergo a complex and precisely timed …

Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark
contrast to the situation that follows loss of neurons or axonal damage, remyelination in the …

Cancer Stem Cells | New England Journal of Medicine Skip to main content The New England
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical …

NG2 cells (also known as polydendrocytes) are a population of CNS cells that are distinct
from neurons, mature oligodendrocytes, astrocytes and microglia. They can be identified by …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

In the vertebrate central nervous system, multipotential cells have been identified in vitro and
in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the …

Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …

Widespread demyelination and axonal loss are the pathological hallmarks of multiple
sclerosis. The multifocal nature of this chronic inflammatory disease of the central nervous …

NG2 glia constitute a fourth major glial cell type in the mammalian central nervous system
(CNS) that is distinct from other cell types. Although circumstantial evidence suggests that …

Promoting remyelination to prevent/reduce neurodegeneration in patients with multiple
sclerosis (MS) is a major therapeutic goal. The longstanding view that the block of …