Increasing attention is being paid to the possibility of applying cancer chemopreventive
agents for individuals at high risk of neoplastic development. For this purpose by natural …

Dehydroepiandrosterone has been thought to have physiological functions other than as an
androgen precursor. The previous studies performed have demonstrated a number of …

Background: Consumption of tomato products or lycopene and energy restriction have been
hypothesized to reduce the risk of human prostate cancer. We investigated the effects of …

A major achievement from 500 million years of evolution is the establishment of a high
secretion rate of dehydroepiandrosterone (DHEA) by the human adrenal glands coupled …

The spread of cancer to bone is invariably fatal, with complex cross-talk between tumor cells
and the bone microenvironment responsible for driving disease progression. By combining …

Re-programming of metabolic pathways is a hallmark of pathological changes in cancer
cells. The expression of certain genes that directly control the rate of key metabolic pathways …

Epidemiological studies have linked fish oil consumption to a decreased incidence of
cancer. The anticancer effects of fish oil are mostly attributed to its content of omega‐3 fatty …

Oxidative/nitrosative stress and generation of proinflammatory cytokines are hallmarks of
inflammation. Because chronic inflammation is implicated in several pathologic conditions in …

Dehydroepiandrosterone (DHEA) is an abundantly produced adrenal steroid whose
biological role has never been clarified. DHEA is a potent uncompetitive inhibitor of …

Gap junctions are intercellular protein channels which provide a pathway for the exchange
of ions and small molecules. This exchange of materials allows metabolic coupling of cells …