SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages

GJ Martínez-Colón, K Ratnasiri, H Chen… - Science Translational …, 2022 - science.org
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …

Insights from Transcriptomics: CD163+ Profibrotic Lung Macrophages in COVID-19

M Bhattacharya - American Journal of Respiratory Cell and …, 2022 - atsjournals.org
Coronavirus disease (COVID-19) begins with upper airway symptoms but proceeds in a
significant proportion of patients to life-threatening infection of the lower respiratory tract …

SARS-CoV2 infection in whole lung primarily targets macrophages that display subset-specific responses

TP Vu Manh, C Gouin, J De Wolf, L Jouneau… - Cellular and Molecular …, 2024 - Springer
Deciphering the initial steps of SARS-CoV-2 infection, that influence COVID-19 outcomes, is
challenging because animal models do not always reproduce human biological processes …

Pulmonary administration of the liposome-based adjuvant CAF01: effect of surface charge on mucosal adjuvant function

OAO Mullertz, P Andersen, D Christensen… - Molecular …, 2022 - ACS Publications
Mucosal surfaces of the lungs represent a major site of entry for airborne pathogens, and
pulmonary administration of vaccines is an attractive strategy to induce protective mucosal …