Mechanism of replication origin melting nucleated by CMG helicase assembly
The activation of eukaryotic origins of replication occurs in temporally separated steps to
ensure that chromosomes are copied only once per cell cycle. First, the MCM helicase is …
ensure that chromosomes are copied only once per cell cycle. First, the MCM helicase is …
Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation
Y Hashimoto, K Sadano, N Miyata, H Ito… - The EMBO …, 2023 - embopress.org
Abstract CMG (Cdc45‐MCM‐GINS) helicase assembly at the replication origin is the
culmination of eukaryotic DNA replication initiation. This process can be reconstructed in …
culmination of eukaryotic DNA replication initiation. This process can be reconstructed in …
DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans
Assembly of the CMG (CDC-45–MCM-2-7–GINS) helicase is the key regulated step during
eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require …
eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require …
The TIMELESS effort for timely DNA replication and protection
JA Patel, H Kim - Cellular and Molecular Life Sciences, 2023 - Springer
Accurate replication of the genome is fundamental to cellular survival and tumor prevention.
The DNA replication fork is vulnerable to DNA lesions and damages that impair replisome …
The DNA replication fork is vulnerable to DNA lesions and damages that impair replisome …
Congenital diseases of DNA replication: clinical phenotypes and molecular mechanisms
M Schmit, AK Bielinsky - International journal of molecular sciences, 2021 - mdpi.com
Deoxyribonucleic acid (DNA) replication can be divided into three major steps: initiation,
elongation and termination. Each time a human cell divides, these steps must be …
elongation and termination. Each time a human cell divides, these steps must be …
Equilibrium between nascent and parental MCM proteins protects replicating genomes
H Sedlackova, MB Rask, R Gupta, C Choudhary… - Nature, 2020 - nature.com
Minichromosome maintenance proteins (MCMs) are DNA-dependent ATPases that bind to
replication origins and license them to support a single round of DNA replication. A large …
replication origins and license them to support a single round of DNA replication. A large …
DONSON is required for CMG helicase assembly in the mammalian cell cycle
C Evrin, V Alvarez, J Ainsworth, R Fujisawa… - EMBO …, 2023 - embopress.org
DONSON is one of 13 genes mutated in a form of primordial microcephalic dwarfism known
as Meier‐Gorlin syndrome. The other 12 encode components of the CDC45‐MCM‐GINS …
as Meier‐Gorlin syndrome. The other 12 encode components of the CDC45‐MCM‐GINS …
[HTML][HTML] DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability
BM Foster, Z Wang, CK Schmidt - Biochemical Journal, 2024 - portlandpress.com
Maintaining stability of the genome requires dedicated DNA repair and signalling processes
that are essential for the faithful duplication and propagation of chromosomes. These DNA …
that are essential for the faithful duplication and propagation of chromosomes. These DNA …
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease
Maintenance of genome stability is of paramount importance for the survival of an organism.
However, genomic integrity is constantly being challenged by various endogenous and …
However, genomic integrity is constantly being challenged by various endogenous and …
Coordinating DNA Replication and Mitosis through Ubiquitin/SUMO and CDK1
A Galarreta, P Valledor, O Fernandez-Capetillo… - International Journal of …, 2021 - mdpi.com
Post-translational modification of the DNA replication machinery by ubiquitin and SUMO
plays key roles in the faithful duplication of the genetic information. Among other functions …
plays key roles in the faithful duplication of the genetic information. Among other functions …