Abstract N-acetyl-5-methoxy-tryptamine (melatonin) is a natural substance produced both by
plants, as a secondary metabolite, and animals, by the pineal gland and other tissues. In …

Priapism is defined as a penile erection that lasts longer than 4 hours after completion of
sexual activity or that is unrelated to sexual activity. 1 Priapism is a disorder of the …

Male infertility is defined as a failure to conceive after 12 months of unprotected intercourse
owing to suspected male reproductive factors. Non-malignant red blood cell disorders are …

Objectives To examine the current molecular therapeutics in the medical treatment of
recurrent ischemic priapism (RIP). To propose a stepwise clinical management paradigm for …

Background: In sickle cell disease (SCD), reduced bioavailability of endothelial NO and
cGMP results in reduced expression of phosphodiesterase type 5 (PDE5), thus impairing the …

Patients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the
absence of sexual arousal. The current pharmacological treatments for SCD-associated …

Testosterone (T) deficiency and erectile dysfunction (ED) are independently functionally and
socially impairing, and their concurrence in men can be challenging to treat. Successful …

Men with sickle cell disease (SCD) frequently experience priapism, defined as prolonged,
painful erections occurring without sexual arousal or desire. This urological emergency can …

Introduction: Priapism is prolonged penile erection in the absence of sexual arousal or
desire and is a devastating condition affecting millions of patients with sickle cell disease …

Hypogonadism is common in men with sickle cell disease (SCD) with prevalence rates as
high as 25%. Testicular failure (primary hypogonadism) is established as the principal cause …