Migration is a polarized cellular process that opposes a protrusive front edge to a retracting
trailing edge. From the front to the rear, actin-mediated forces sequentially promote cell …

The proteolytic processing of collagen (collagenolysis) is critical in development and
homeostasis, but also contributes to numerous pathologies. Mammalian interstitial …

Invasive cell migration through tissue barriers requires pericellular remodelling of
extracellular matrix (ECM) executed by cell-surface proteases, particularly membrane-type-1 …

Directional cell migration requires force generation that relies on the coordinated
remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin …

Matrix metalloproteases (MMPs) are key regulatory molecules in the formation, remodeling,
and degradation of extracellular matrix (ECM) components in both physiological and …

Tumor cell migration and the concomitant degradation of extracellular matrix (ECM) are two
essential steps in the metastatic process. It is well established that focal adhesions (FAs) …

Invadopodia are invasive protrusions with proteolytic activity uniquely found in tumor cells.
Cortactin phosphorylation is a key step during invadopodia maturation, regulating Nck1 …

For cancer progression and metastatic dissemination, cancer cells migrate and penetrate
through extracellular tissues. Cancer invasion is frequently facilitated by proteolytic …

In multicellular organisms, uncontrolled movement of cells can contribute to pathological
conditions, such as multiple sclerosis and cancer. In highly aggressive tumors, the …

Gastric cancer is one of the leading causes of the cancer-related mortality worldwide. The
etiology of this disease is complex and involves genetic predisposition and environmental …