Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules
ZX He, YP Gong, X Zhang, LY Ma, W Zhao - European journal of medicinal …, 2021 - Elsevier
Identification of potent anticancer agents with high selectivity and low toxicity remains on the
way to human health. Pyridazine featuring advantageous physicochemical properties and …
way to human health. Pyridazine featuring advantageous physicochemical properties and …
Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents-A recent update
PG Jain, BD Patel - European journal of medicinal chemistry, 2019 - Elsevier
Abstract Poly (ADP-ribose) Polymerase1 (PARP1) is a member of 17 membered PARP
family having diversified biological functions such as synthetic lethality, DNA repair …
family having diversified biological functions such as synthetic lethality, DNA repair …
Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents
Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of
certain inflammatory mediators associated with cancer. In the present work, a new series of …
certain inflammatory mediators associated with cancer. In the present work, a new series of …
Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma
A series of new VEGFR-2 inhibitors were designed, synthesized and evaluated for their anti-
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
[HTML][HTML] 1, 3, 4-Oxadiazole-containing hybrids as potential anticancer agents: Recent developments, mechanism of action and structure-activity relationships
S Nayak, SL Gaonkar, EA Musad… - Journal of Saudi Chemical …, 2021 - Elsevier
Chemotherapy is an important therapeutic approach for the treatment of cancer. Currently,
many anticancer drugs are available in the market that plays an important role in cancer …
many anticancer drugs are available in the market that plays an important role in cancer …
Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy
X Peng, W Pan, F Jiang, W Chen, Z Qi, W Peng… - Pharmacological …, 2022 - Elsevier
Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as
DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP …
DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP …
Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
A Sabt, OM Abdelhafez, RS El-Haggar… - Journal of enzyme …, 2018 - Taylor & Francis
Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives
bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro …
bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro …
Multi-therapies based on PARP inhibition: potential therapeutic approaches for cancer treatment
J Zhang, Y Gao, Z Zhang, J Zhao, W Jia… - Journal of Medicinal …, 2022 - ACS Publications
The nuclear enzymes called poly (ADP-ribose) polymerases (PARPs) are known to catalyze
the process of PARylation, which plays a vital role in various cellular functions. They have …
the process of PARylation, which plays a vital role in various cellular functions. They have …
Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents
In connection with our research program on the development of novel anticancer
candidates, herein we report the design and synthesis of novel series of 1-(2-methyl-6 …
candidates, herein we report the design and synthesis of novel series of 1-(2-methyl-6 …
Terminalia chebula Polyphenol and Near-Infrared Dye-Loaded Poly(lactic acid) Nanoparticles for Imaging and Photothermal Therapy of Cancer Cells
Photothermal/photodynamic therapies (PTT/PDT) are multimodal approaches employing
near-infrared (NIR) light-responsive photosensitizers for cancer treatment. In the current …
near-infrared (NIR) light-responsive photosensitizers for cancer treatment. In the current …