Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - Elsevier
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy

Y Liu, S Shao, H Guo - Life sciences, 2020 - Elsevier
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that
affects approximately half of patients with diabetes. Current treatment regimens cannot treat …

[HTML][HTML] Oxytocin is a principal hormone that exerts part of its effects by active fragments

KU Moberg, L Handlin, K Kendall-Tackett… - Medical hypotheses, 2019 - Elsevier
Oxytocin is a nonapeptide consisting of a cyclic six amino-acid structure and a tail of three
amino acids. It was originally known for its ability to induce milk ejection and to stimulate …

Approaches mediating oxytocin regulation of the immune system

T Li, P Wang, SC Wang, YF Wang - Frontiers in immunology, 2017 - frontiersin.org
The hypothalamic neuroendocrine system is mainly composed of the neural structures
regulating hormone secretion from the pituitary gland and has been considered as the …

Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients?

B Buemann, D Marazziti… - The World Journal of …, 2021 - Taylor & Francis
Objectives Based on its well-documented anti-inflammatory and restorative properties we
propose trials with the natural hormone oxytocin for treatment of hospitalised Covid-19 …

Oxytocin receptor signaling in vascular function and stroke

EC McKay, SE Counts - Frontiers in Neuroscience, 2020 - frontiersin.org
The oxytocin receptor (OXTR) is a G protein-coupled receptor with a diverse repertoire of
intracellular signaling pathways, which are activated in response to binding oxytocin (OXT) …

Application of stem cells, growth factors, small molecules, and biological macromolecules on nerve regeneration: a review and future direction

S Nemati Mahand, N Niknami… - … Journal of Polymeric …, 2024 - Taylor & Francis
The nervous system is a vital component of the human body, and its dysfunction can have
fatal consequences or severe adverse effects. After significant disabling conditions, the …

Bergenin reduces experimental painful diabetic neuropathy by restoring redox and immune homeostasis in the nervous system

CF Villarreal, DS Santos, PSS Lauria, KB Gama… - International Journal of …, 2020 - mdpi.com
Diabetic neuropathy is a frequent complication of diabetes. Symptoms include neuropathic
pain and sensory alterations—no effective treatments are currently available. This work …

The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice

J Zhu, Y Li, J Liang, J Li, K Huang, J Li, C Liu - Toxicology Letters, 2021 - Elsevier
Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and
solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose …