Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …

Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …

Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

Focal adhesion kinase (FAK) is an integrin-associated protein tyrosine kinase that is
frequently overexpressed in advanced human cancers. Recent studies have demonstrated …

FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the
progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic …

Cancer-associated fibroblasts (CAFs) are activated fibroblasts that constitute the major
components of tumor microenvironment (TME) and play crucial roles in tumor development …

Pancreatic cancer is characterized by an extensive fibroinflammatory microenvironment.
During carcinogenesis, normal stromal cells are converted to cytokine-high cancer …

Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

Gene copy number alterations, tumor cell stemness, and the development of platinum
chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) …