Technologies based on surface plasmon resonance (SPR) have allowed rapid, label‐free
characterization of protein‐protein and protein‐small molecule interactions. SPR has …

Abstract We identified 1113 articles (103 reviews, 1010 primary research articles) published
in 2005 that describe experiments performed using commercially available optical …

G-protein-coupled receptors (GPCRs), a superfamily of cell-surface receptors that are the
targets of about 40% of prescription drugs on the market, can sense numerous critical …

G protein-coupled receptors (GPCR) are integral membrane proteins that transmit signals
from external stimuli to the cell interior via activation of GTP-binding proteins (G proteins) …

Measuring the binding kinetics of antibodies to intact membrane proteins by surface
plasmon resonance has been challenging largely because of the inherent difficulties in …

Directed evolution is a technique that enables the identification of mutants of a particular
protein that carry a desired property by successive rounds of random mutagenesis …

Despite their clinical importance, detailed analysis of ligand binding at G-protein coupled
receptors (GPCRs) has proved difficult. Here we successfully measure the binding of a …

With the advent of the recent determination of high-resolution crystal structures of bovine
rhodopsin and human β2 adrenergic receptor (β2AR), there are still many structure-function …

Objectives To explore the possible role of hetero-oligomerization among the human UDP-
glucuronosyltransferases in attenuating the consequences of the pathological Y486D …

G-protein-coupled receptors (GPCRs) are a large family of seven transmembrane proteins
that influence a considerable number of cellular events. For this reason, they are one of the …