COVID-19 and long COVID: disruption of the neurovascular unit, blood-brain barrier, and tight junctions

D Kempuraj, KK Aenlle, J Cohen… - The …, 2024 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …

The role of immune activation and antigen persistence in acute and long COVID

S Opsteen, JK Files, T Fram… - Journal of Investigative …, 2023 - journals.sagepub.com
In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered the
global coronavirus disease 2019 (COVID-19) pandemic. Although most infections cause a …

Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers

KC Marques, JAS Quaresma… - Frontiers in cardiovascular …, 2023 - frontiersin.org
Long COVID is characterized by persistent signs and symptoms that continue or develop for
more than 4 weeks after acute COVID-19 infection. Patients with Long COVID experience a …

Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers

RF Damiano, CCA Rocca, AP Serafim… - Frontiers in …, 2023 - frontiersin.org
Objective To analyze the potential impact of sociodemographic, clinical and biological
factors on the long-term cognitive outcome of patients who survived moderate and severe …

Ox-inflammasome involvement in neuroinflammation

A Vallese, V Cordone, A Pecorelli, G Valacchi - Free Radical Biology and …, 2023 - Elsevier
Neuroinflammation plays a crucial role in the onset and the progression of several
neuropathologies, from neurodegenerative disorders to migraine, from Rett syndrome to …

Long‐term neurological dysfunction associated with COVID‐19: Lessons from influenza and inflammatory diseases?

P Volk, M Rahmani Manesh, ME Warren… - Journal of …, 2024 - Wiley Online Library
As the COVID‐19 pandemic persists, SARS‐CoV‐2 infection is increasingly associated with
long‐term neurological side effects including cognitive impairment, fatigue, depression, and …

SARS‐CoV‐2 ORF3a expression in brain disrupts the autophagy–lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis

H Zhu, C Byrnes, YT Lee, G Tuymetova… - The FASEB …, 2023 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causes injury to
multiple organ systems, including the brain. SARS‐CoV‐2's neuropathological mechanisms …

The COVID-19 inflammation and high mortality mechanism trigger

S Stróż, P Kosiorek, A Stasiak-Barmuta - Immunogenetics, 2024 - Springer
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) lasted from March 2020 to May 2023, infecting over 689 million and causing …

Susceptibility of SARS-CoV2 infection in children

N Cotugno, D Amodio, D Buonsenso… - European journal of …, 2023 - Springer
Coronavirus disease 2019 in children presents with distinct phenotype in comparison to
adults. Overall, the pediatric infection with a generally milder clinical course of the acute …

Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification

J Class, LM Simons, R Lorenzo-Redondo, JG Achi… - Nature …, 2024 - nature.com
Severe coronavirus disease 2019 and post-acute sequelae of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection are associated with neurological …