Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

The epilepsies are a group of complex neurological disorders characterised by recurrent
seizures. Approximately 30% of patients fail to respond to anti-seizure medications, despite …

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy; it is considered a
network disorder associated with structural changes. Incomplete knowledge of the …

Aims To identify transcriptome signatures underlying epileptogenesis in temporal lobe
epilepsy (TLE). Methods Robust rank aggregation analysis was used to integrate multiple …

Mesial temporal lobe epilepsy (MTLE) is one of the most common types of focal epilepsy in
the adult population. MTLE is frequently associated with a specific histopathological lesion …

Mesial temporal lobe epilepsy (mTLE) is a common form of epilepsy and is characterized by
recurrent spontaneous seizures originating from the temporal lobe. The majority of mTLE …

Background Glioblastoma multiforme (GBM) is the most malignant tumor in human brain.
Diagnosis and treatment of GBM may lead to psychological disorders such as depressive …

Objectives The prevalence of generalised anxiety disorder (GAD) is high. However, the
underlying mechanisms remain elusive. Proteomics techniques can be employed to assess …

Acute brain insults trigger diverse cellular and signaling responses and often precipitate
epilepsy. The cellular, molecular and signaling events relevant to the emergence of the …

Ghrelin is a neuropeptide that has various physiological functions and has been
demonstrated to be neuroprotective in a number of neurological disease models. However …