The kinesin class of microtubule-associated motor proteins present attractive anticancer
targets owing to their roles in key functions in dividing cells. Two interpolar mitotic kinesins …

There is a strong need for new antimitotic drugs that overcome the limitations of the currently
used antitubulin compounds, mainly neurotoxicity and the development of resistance. One of …

Kinesin-5 is required for forming the bipolar spindle during mitosis. Its motor domain, which
contains nucleotide and microtubule binding sites and mechanical elements to generate …

Eg5 is a homotetrameric kinesin-5 motor protein that generates outward force on the
overlapping, antiparallel microtubules (MTs) of the mitotic spindle. Upon binding an MT, an …

Kinesin motors play central roles in establishing and maintaining the mitotic spindle during
cell division. Unlike most other kinesins, Cin8, a kinesin-5 motor in Saccharomyces …

Kinesin Eg5 is a plus-end-directed microtubule-based motor that is essential for bipolar
spindle formation during eukaryotic cell division. Loop L5 of mitotic kinesin Eg5 is a key …

Kinesin-5 motors are members of a superfamily of microtubule-dependent ATPases and are
widely conserved among eukaryotes. Kinesin-5s typically form homotetramers with pairs of …

Tonantzitlolone A, a diterpene isolated from the Mexican plant Stillingia sanguinolenta,
shows cytostatic activity. Both the natural product tonantzitlolone A and its synthetic …

The kinesin-5 family member, Eg5, plays very important role in the mitosis. As a mitotic
protein, Eg5 is the target of various mitotic inhibitors. There are two targeting pockets in the …

We have employed molecular dynamics (MD) simulation to investigate, with atomic details,
the structural dynamics and energetics of three major ATPase states (ADP, APO, and ATP …