Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Work during the past 14 years has shown that mitochondria are the primary site for the
biosynthesis of iron–sulfur (Fe/S) clusters. In fact, it is this process that renders mitochondria …

Iron–sulfur (Fe/S) clusters belong to the most ancient protein cofactors in life, and fulfill
functions in electron transport, enzyme catalysis, homeostatic regulation, and sulfur …

Members of the bacterial and mitochondrial iron–sulfur cluster (ISC) assembly machinery
include the so-called A-type ISC proteins, which support the assembly of a subset of Fe/S …

Many metabolic pathways and cellular processes occurring in most sub-cellular
compartments depend on the functioning of iron-sulfur (Fe-S) proteins, whose cofactors are …

Cobalt is an essential trace element in both prokaryotes and eukaryotes. Nevertheless, it
occurs less frequently in metalloproteins than other transition metals. This low occurrence …

Most eukaryotes contain iron-sulfur cluster (ISC) assembly proteins related to
Saccharomyces cerevisiae Isa1 and Isa2. We show here that Isa1 but not Isa2 can be …

Friedreich ataxia (FRDA) is an autosomal recessive, multi-systemic degenerative disease
that results from reduced synthesis of the mitochondrial protein frataxin. Frataxin has been …

Abstract Iron–sulfur (Fe–S) clusters are inorganic cofactors that are ubiquitous and essential.
Due to their chemical versatility, Fe–S clusters are implicated in a wide range of protein …