Steven M. Greenberg, MD, PhD, FAHA, Chair; Wendy C. Ziai, MD, MPH, FAHA, Vice Chair;
Charlotte Cordonnier, MD, PhD; Dar Dowlatshahi, MD, PhD, FAHA; Brandon Francis, MD …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

Objective To investigate the aetiology, subsequent preventive strategies and outcomes of
stroke despite anticoagulation in patients with atrial fibrillation (AF). Methods We analysed …

Whilst there is a clear clinical benefit of oral anticoagulation (OAC) in patients with atrial
fibrillation (AF) and venous thromboembolism (VTE) in reducing the risks of …

BACKGROUND: Atrial fibrillation is a major risk factor for stroke and silent brain infarcts. We
studied whether a multimodal approach offers additional insights to the CHA2DS2-VASc …

Stroke is the leading cause of functional disability worldwide, with increasing prevalence in
adults. Given the considerable negative impact on patients' quality of life and the financial …

Balancing the risks of recurrent ischemia and antithrombotic-associated bleeding,
particularly intracranial hemorrhage (ICH), is a key challenge in the secondary prevention of …

Cerebral small vessel disease (cSVD)—a common cause of stroke and vascular dementia—
is a group of clinical syndromes that affects the brain's small vessels, including arterioles …

Cyclin B2 (CCNB2) belongs to type B cell cycle family protein, which is located on
chromosome 15q22, and it binds to cyclin-dependent kinases (CDKs) to regulate their …

Objective To investigate the safety and effectiveness of direct oral anticoagulants (DOAC)
versus vitamin K antagonists (VKA) after recent stroke in patients with atrial fibrillation (AF) …