Tumor‐microenvironment‐responsive nanomedicine for enhanced cancer immunotherapy

S Peng, F Xiao, M Chen, H Gao - Advanced Science, 2022 - Wiley Online Library
The past decades have witnessed great progress in cancer immunotherapy, which has
profoundly revolutionized oncology, whereas low patient response rates and potential …

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

G Gunaydin, ME Gedik, S Ayan - Frontiers in chemistry, 2021 - frontiersin.org
Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long
time and photosensitizers (PS) can be used in various types of tumors. Originally, light is an …

Multienzyme-like reactivity cooperatively impairs glutathione peroxidase 4 and ferroptosis suppressor protein 1 pathways in triple-negative breast cancer for sensitized …

K Li, C Lin, M Li, K Xu, Y He, Y Mao, L Lu, W Geng… - ACS …, 2022 - ACS Publications
Ferroptosis is a recently discovered route of regulated cell death that offers the opportunities
for the treatment of chemotherapy-resistant tumor indications, but its efficacy can be affected …

Emerging combination strategies with phototherapy in cancer nanomedicine

Z Xie, T Fan, J An, W Choi, Y Duo, Y Ge… - Chemical Society …, 2020 - pubs.rsc.org
Optical techniques using developed laser and optical devices have made a profound impact
on modern medicine, with “biomedical optics” becoming an emerging field. Sophisticated …

Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2, 3-dioxygenase-blockade tumor immunotherapy

L Dai, M Yao, Z Fu, X Li, X Zheng, S Meng… - Nature …, 2022 - nature.com
Inhibited immune response and low levels of delivery restrict starvation cancer therapy
efficacy. Here, we report on the co-delivery of glucose oxidase (GOx) and indoleamine 2, 3 …

Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms

Y Zi, K Yang, J He, Z Wu, J Liu, W Zhang - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …

Stimuli‐responsive nanoparticles for controlled drug delivery in synergistic cancer immunotherapy

J Zhang, Y Lin, Z Lin, Q Wei, J Qian, R Ruan… - Advanced …, 2022 - Wiley Online Library
Cancer immunotherapy has achieved promising clinical progress over the recent years for
its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low …

Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

L Huang, Y Li, Y Du, Y Zhang, X Wang, Y Ding… - Nature …, 2019 - nature.com
One of the main challenges for immune checkpoint blockade antibodies lies in malignancies
with limited T-cell responses or immunologically “cold” tumors. Inspired by the capability of …

Immunotherapy for ovarian cancer: adjuvant, combination, and neoadjuvant

C Yang, BR Xia, ZC Zhang, YJ Zhang, G Lou… - Frontiers in …, 2020 - frontiersin.org
Ovarian cancer is the most lethal gynecologic malignancy. Surgery and chemotherapy are
the primary treatments for ovarian cancer; however, patients often succumb to recurrence …

Smart transformable nanoparticles for enhanced tumor theranostics

J Chen, Z Jiang, YS Zhang, J Ding, X Chen - Applied Physics Reviews, 2021 - pubs.aip.org
The physical morphologies of nanoparticles, especially size and shape, always significantly
influence their biological behaviors. In the past, nanoparticles with constant physical …