cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers
Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy
resistance, and is associated with poor prognosis. CIN leads to micronuclei that release …
resistance, and is associated with poor prognosis. CIN leads to micronuclei that release …
Unlocking the NF-κB conundrum: embracing complexity to achieve specificity
F Begalli, J Bennett, D Capece, D Verzella, D D'Andrea… - Biomedicines, 2017 - mdpi.com
Transcription factors of the nuclear factor κB (NF-κB) family are central coordinating
regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB …
regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB …
[HTML][HTML] WW domain-containing oxidoreductase in neuronal injury and neurological diseases
HT Chang, CC Liu, ST Chen, YV Yap, NS Chang… - Oncotarget, 2014 - ncbi.nlm.nih.gov
The human and mouse WWOX/Wwox gene encodes a candidate tumor suppressor WW
domain-containing oxidoreductase protein. This gene is located on a common fragile site …
domain-containing oxidoreductase protein. This gene is located on a common fragile site …
Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-κB pathway …
EF24 and F35 both were effective monocarbonyl curcumin analogues (MCACs) with
excellent anti-tumor activity, however, drug defect such as toxicity may limit their further …
excellent anti-tumor activity, however, drug defect such as toxicity may limit their further …
PLEK2, RRM2, GCSH: A Novel WWOX-Dependent Biomarker Triad of Glioblastoma at the Crossroads of Cytoskeleton Reorganization and Metabolism Alterations
Ż Kałuzińska, D Kołat, AK Bednarek, E Płuciennik - Cancers, 2021 - mdpi.com
Simple Summary Cytoskeleton reorganization affects the malignancy of glioblastoma. The
WWOX gene is a tumor suppressor in glioblastoma and was found to modulate the …
WWOX gene is a tumor suppressor in glioblastoma and was found to modulate the …
[HTML][HTML] Photoreceptor cell calcium dysregulation and calpain activation promote pathogenic photoreceptor oxidative stress and inflammation in prodromal diabetic …
A Saadane, Y Du, WB Thoreson, M Miyagi… - The American journal of …, 2021 - Elsevier
This study tested the hypothesis that diabetes promotes a greater than normal cytosolic
calcium level in rod cells that activates a Ca 2+-sensitive protease, calpain, resulting in …
calcium level in rod cells that activates a Ca 2+-sensitive protease, calpain, resulting in …
The WWOX gene in brain development and pathology
K Kośla, Ż Kałuzińska… - Experimental Biology and …, 2020 - journals.sagepub.com
Shortly after its discovery in 2000, WWOX was hailed as a tumor suppressor gene. In
subsequent years of research, this function was confirmed indisputably. Majority of tumors …
subsequent years of research, this function was confirmed indisputably. Majority of tumors …
Engagement of specific intracellular pathways in the inflammation-based reprotoxicity effect of small-size silver nanoparticles on spermatogonia and spermatocytes in …
Male infertility is a serious ongoing problem, whose causes have not yet been clearly
identified. However, since human exposure to silver nanoparticles (AgNPs) has recently …
identified. However, since human exposure to silver nanoparticles (AgNPs) has recently …
Wwox modulates ros-dependent senescence in bladder cancer
CW Liu, PH Chen, TJ Yu, KJ Lin, LC Chang - Molecules, 2022 - mdpi.com
The tumor-suppressor gene, WW domain-containing oxidoreductase (WWOX), has been
found to be lost in various types of cancers. ROS result as a tightly regulated signaling …
found to be lost in various types of cancers. ROS result as a tightly regulated signaling …